Over-the-Counter Supplements That Can Help with Depression

Depression stems from more than just brain chemistry—it can involve nutrient imbalances, stress hormones, and inflammation. This guide highlights science-backed supplements like St. John’s wort, omega-3 fish oil, SAMe, L-methylfolate, and others that target neurotransmitter production or reduce oxidative stress. Each compound has unique benefits and cautionary notes, making them possible allies in supporting mood—even alongside standard medication or therapy.